The role of the adapter protein PICALM (phosphatidylinositol-binding clathrin assembly protein) in the development of Alzheimer’s disease is well documented. Researchers from the German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), the German Center for Diabetes Research (DZD), ETH Zurich and the University of Cambridge have now for the first time studied the role of PICALM in white adipose tissue and its importance for metabolic health. They demonstrated that a reduced expression of PICALM improves insulin sensitivity and glucose transport in fat cells.
This article was originally published on MedicalXpress.com
