Cocaine, a drug of abuse, activates just a portion—10% to 20%—of the neurons in the brain’s nucleus accumbens, a critical region linked to motivation and addiction. Though small in numbers, this activated neuronal population strongly controls drug-related behavior through downstream changes in gene expression, nerve synapses, neural circuitry and neural function that lead to behavioral change, including addiction.
This article was originally published on MedicalXpress.com
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