Simultaneously targeting lysosomal enzyme and KRAS-MAPK pathway eradicates pancreatic tumors in preclinical models

Pancreatic cancer is a leading cause of cancer-related death, with a five-year survival rate of 13%. The high mortality is largely due to a lack of effective therapy options. In a recent paper published in Nature, researchers from the University of Michigan have discovered that simultaneously targeting PIKfyve and KRAS-MAPK can eliminate tumors in preclinical human and mouse models.

This article was originally published on MedicalXpress.com

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