Pediatric high-grade gliomas: Research reveals effective targeting with avapritinib

Pediatric high-grade gliomas, particularly H3K27M diffuse midline gliomas (DMG), are aggressive malignant brain tumors with a poor prognosis. Previous research suggests that platelet-derived growth factor receptor alpha (PDGFRA) appears to play a multifaceted role in the pathogenesis of both adult and pediatric high-grade gliomas. Not only are genetic alterations of PDGFRA common in patients with pediatric high-grade gliomas, but elevated PDGFRA expression has been shown to be key in driving growth of DMG tumors.

This article was originally published on MedicalXpress.com

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