Cancer

New research shows first population-level evidence globally that a national HPV vaccination program can be highly effective in a high HIV-prevalence setting. In South Africa, where the burden of HIV remains high, women living with […]

Obesity increases the body’s need for insulin, forcing cells in the pancreas known as beta cells to ramp up insulin production to maintain blood sugar levels. Scientists have thought that this excessive insulin secretion is […]

Two new studies from investigators at Mass General Brigham challenge a decades-old assumption that the thymus, an organ best known for its role in establishing immune function in childhood, becomes irrelevant in adulthood. Using artificial […]

Researchers have discovered an antioxidant, glutathione, that cancer cells appear to be “addicted to” as fuel, opening new pathways for investigation and a potential drug that can restrict the way tumors use this nutrient.This article […]

For years, one of the most powerful weapons against certain blood cancers, called CAR-T cell therapy, has required an elaborate process: Doctors extract a patient’s immune cells, ship them to a specialized facility where they’re […]

Cancer-fighting T cells do not simply “run out of energy.” They are molecularly reprogrammed. For years, mitochondrial dysfunction has been recognized as a hallmark of exhausted T cells in tumors. Yet how metabolic stress translates […]

Researchers at the Icahn School of Medicine at Mount Sinai and the Mount Sinai Tisch Cancer Center have discovered a biological pathway that helps explain why some bladder cancers do not respond well to immunotherapy. […]

A research team affiliated with UNIST has made a significant discovery explaining why liver cancers associated with obesity and metabolic disorders tend to be more aggressive and less responsive to conventional treatments. The study reveals […]

Northwestern Medicine scientists have discovered that specialized immune cells within the glioblastoma tumor metabolize fructose to suppress immune responses and promote tumor growth, reports a study published in the Proceedings of the National Academy of […]

Detection of a bowel cancer marker (CDH1) in wastewater may offer a new community-level early warning system for the disease, suggests a proof-of-concept study published in the Journal of Epidemiology and Community Health. Wastewater surveillance […]