Stress-related disorders stem from the interplay of genetic susceptibility and stress exposure, shaping gene and protein expression through epigenetic modifications across the lifespan. Studies on postmortem brains of post-traumatic stress disorder (PTSD) and major depression (MDD) patients, compared to neurotypical controls, have revealed genetic overlap, sex differences, and immune and interneuron signaling involvement, yet lack integrative analyses.
This article was originally published on MedicalXpress.com
