Researchers at Tsukuba University have discovered that the increase in regulatory T (Treg) cells, which typically suppress immune responses, does not adequately control elderly-onset rheumatoid arthritis. In the arthritic environment, Treg cells exhibit altered metabolic activity, reduced suppressive function, and increased PD-1 expression. Moreover, increased type I interferon signaling has been identified as a contributing factor to this dysfunction.
This article was originally published on MedicalXpress.com
