A single enzyme keeps neuroblastoma alive—how to shut it off

The tumor begins before birth. Somewhere in the developing fetus, neural crest cells that should have matured into adrenal tissue or sympathetic ganglia take a wrong turn, and a child is born harboring a malignancy that may not declare itself for months. Neuroblastoma accounts for roughly 28% of all cancers diagnosed in infants across Europe and the United States. In its gentlest form, it regresses on its own, a fire that puts itself out. In its cruelest, it metastasizes with a velocity that makes oncologists reach for words they would rather not use in front of parents.

This article was originally published on MedicalXpress.com

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