One of oncology’s biggest challenges is that the same treatment can work well for some patients but fail completely in others. A study published in Nature Communications, by a multidisciplinary team led by Dr. Louise Fets at the LMS, has mapped the distribution of a type of targeted treatment, known as PARP inhibitors, using advanced imaging techniques and patient ovarian tumor samples. The research reveals that the buildup of these drugs in lysosomes—small compartments inside cells that normally act as “recycling centers”—can trap and release certain drugs over time, shaping how well treatments work.
This article was originally published on MedicalXpress.com
