Retrotransposon drives cancer by altering 3D genome structure

Scientists at St. Jude Children’s Research Hospital have revealed previously unappreciated roles for the retrotransposon LINE-1 in shaping the cancer genome structure and regulation. Retrotransposons are mobile DNA pieces, comprising much of the human genome. These so-called “jumping genes” can copy and insert themselves throughout the genome, contributing to various diseases, including cancer.

This article was originally published on MedicalXpress.com

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