uPAR-targeted CAR T cells shrank solid tumors and cleared metastases in mice

Chimeric antigen receptor T-cell therapy—CAR T for short—has been a major advance in treating blood cancers like leukemia and lymphoma. But the immunotherapy has struggled against solid tumors for two main reasons: Tumor cells often don’t share one consistent surface target, and many solid tumors are protected by a dense network of scar tissue and immune-suppressive cells that blocks T cells.

This article was originally published on MedicalXpress.com

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