Substance use disorder affects 20 million Americans, and more than 100,000 people died from a drug overdose in 2021, according to the Centers for Disease Control and Prevention. While the medication methadone has the strongest evidence-based effectiveness to prevent relapse, about half of patients drop out of their treatment within one year of initiation. The solution could lie in taking a simple “sugar pill” or placebo along with the methadone, according to a randomized clinical trial led by researchers at the University of Maryland School of Medicine.
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