Heterogeneous development of β-cell populations in diabetes-resistant and diabetes-susceptible mice

Progressive dysfunction and failure of insulin-releasing β-cells is a hallmark of type 2 diabetes (T2D). DZD researchers have now shown that diabetes-resistant and diabetes-susceptible mice respond differently to a carbohydrate-rich diet. The gene expression of the beta cells of the diabetes-resistant mice changed in such a way that a protective beta cell cluster developed. In diabetic-prone mice, a failure to adjust gene expression in response to rising blood glucose levels led to increased metabolic stress and beta cell failure. The study was published in the journal Diabetes.

This article was originally published on MedicalXpress.com

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