Researchers refine understanding of fetal hemoglobin regulation

Researchers at Children’s Hospital of Philadelphia (CHOP) have discovered a new part of the regulatory cascade responsible for silencing fetal hemoglobin in adult cells. The findings, published today in Nature Genetics, refine scientists’ understanding of the process that turns fetal hemoglobin “off” and adult hemoglobin “on,” which could have therapeutic implications for those with blood disorders like sickle cell disease and beta-thalassemia.

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