Clonal hematopoiesis is a biological process in which a blood stem cell (the population that gives rise to a variety of blood cell types) acquires an advantageous mutation and outgrows neighboring cells. Clonal hematopoiesis is diagnosed when this mutation is present in 2% of all blood cells in a given individual. The advantageous mutations that drive clonal hematopoiesis are under positive selection, just like mutations in cancer genes which are responsible for the malignisation of cells.
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