From cavefish to humans: Evolution of metabolism in cavefish may provide insight into treatments for a host of diseases

New research from the Stowers Institute for Medical Research examines how cavefish, surface-dwelling river fish that flooded into underground cave systems over 100,000 years ago, developed unique metabolic adaptations to survive in nutrient-scarce environments. The study, published online in Nature Genetics on May 12, 2022, led by Jaya Krishnan, Ph.D., a senior research associate in the lab of Nicolas Rohner, Ph.D., created a genome-wide map of liver tissue for two independent colonies of cavefish along with river fish to understand how cavefish metabolism evolved and how this may be applicable for humans.

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